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Scientists have identified several genetic mutations associated with PD, including the alpha-synuclein gene, and many more genes have been tentatively linked to the disorder.
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Among forms of primary dystonia, the most common (and the most debilitating) is generalized dystonia, which affects the legs or one leg and the trunk, plus other regions, most commonly the arms.
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Home modifications (wheelchair ramps, grab bars, and handrails) can help improve functional abilities and independent living.
MAO-B inhibitors cause dopamine to accumulate in surviving nerve cells and reduce the symptoms of PD.
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It partially blocks striatal cholinergic receptors, and by blocking muscarinic cholinergic receptors in the CNS, benztropine reduces the excessive cholinergic activity present in parkinsonism and related states.
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