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However, genetic studies have shown that resistance of M tuberculosis to antimycobacterial drugs is the consequence of spontaneous mutations in genes that encode either the target of the drug, or enzymes that are involved in drug activation.

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This combination was approved by the FDA in November 2014 for patients aged 2 years and older who are at high risk for developing active TB disease(including those in close contact with active TB patients, patients who have had a recent conversion to a positive tuberculin skin test, HIV-infected patients, and those with pulmonary fibrosis on radiograph).

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