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In general, after two weeks of treatment with antiobiotics the infection is contained and cannot be spread to others.
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The 1994 US CDC guidelines for tuberculosis erroneously cite Slutkin as evidence that a nine-month regimen using only isoniazid and rifampicin is acceptable, but almost all of the patients in that study received ethambutol for the first two to three months (although this is not obvious from the abstract of that article).
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However, genetic studies have shown that resistance of M tuberculosis to antimycobacterial drugs is the consequence of spontaneous mutations in genes that encode either the target of the drug, or enzymes that are involved in drug activation.
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In most instances, enzyme levels return to normal and generally, there is no necessity to discontinue medication during the period of mild serum transaminase elevation.
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Repeat dosing may be needed for persistent seizure activity and may also be used to reverse deep coma.
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This combination was approved by the FDA in November 2014 for patients aged 2 years and older who are at high risk for developing active TB disease(including those in close contact with active TB patients, patients who have had a recent conversion to a positive tuberculin skin test, HIV-infected patients, and those with pulmonary fibrosis on radiograph).
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