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How long does it take IV Zofran to work? Since the time to reach peak concentration is 0.5 to 2 hours after oral ingestion, the drug should be administered at least 30 minutes before chemotherapy. Possible alternative ways of administration of ondansetron include intramuscular, subcutaneous and rectal administration, and oral controlled-release formulations.
Can you take Zofran on an empty stomach? Ondansetron (Zofran) is an anti-nausea medicine. Medicines generally work faster on an empty stomach, an hour before food or 2 hours after. The orally disintegrating tablets or oral soluble films are absorbed very quickly into the blood stream so start to work rapidly.
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