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Are typical or atypical antipsychotics better? Meta-analyses confirm that atypical antipsychotics cause fewer extra pyramidal adverse effects than typical drugs, particularly haloperidol. It has been strongly suggested that this advantage disappears for risperidone, olanzapine and amisulpride if low doses of typical antipsychotics are used in comparison.
How long does IV haloperidol take to work? Oral antipsychotic medications require days to weeks to take effect. Intramuscular medication reaches the brain within 30 minutes (intravenous injection does so within minutes), but only haloperidol and ziprasidone are currently available and FDA-approved for IM use.
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