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No clinically meaningful difference in lipid profile was found in patients with DM treated with ranolazine compared with placebo.
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If you are pregnant or nursing, you should discuss the safety and risks versus benefits with your physician.
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Health Science Centers Institute of Biosciences and Technology in Houston, noted that the study was relatively small.
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As used herein, “consisting essentially of” means that the invention may include ingredients in addition to those recited in the claim, but only if the additional ingredients do not materially alter the basic and novel characteristics of the claimed invention.
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Anginal pain is caused when heart muscle does not get enough oxygen.
The increase in adverse events seen with the 1500 mg dose in MARISA is disproportionately larger than the increase in anti-anginal efficacy; thus, the 1500 mg twice-daily dose is not recommended for clinical use.
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Baseline echocardiographic and invasive hemodynamic parameter data were measured for all 11 study participants, because all participants enrolled in the study completed baseline cardiac testing.
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In a preferred embodiment, a patient is selected for treatment with ranolazine by determining if that patient is suffering from, or is at a risk of suffering from, coronary microvascular disease prior to the administration of ranolazine.
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Any previous antianginal drugs used by the patients were discontinued under medical supervision.
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For pretty much all kinds of heart disease, lifestyle changes such as a hearthealthy diet, daily exercise, weight loss, smoking cessation, and stress management are key.
Specifically, this invention is particularly useful for treating a high risk coronary disease patient with a subsequent acute coronary disease event by treating a patient with ranolazine.
Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure.
Acute management of PD typically involves sedative measures in efforts to relax the patient and reduce his or her anxiety.
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Ranolazine in combination with beta blockers can be useful when used for relief of anginal symptoms when initial treatment with beta blockers is not successful in patients with SIHD (Class IIb A).
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Several prognostic indices have been used to relate severity of disease to the risk of subsequent cardiac events; the simplest and most widely used is the classification of disease into one-vessel, two-vessel, three-vessel, or left main (LM) stem CAD.
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After obtaining written informed consent, we randomly assigned 2287 of 3071 eligible patients to PCI plus optimal medical therapy or to optimal medical therapy alone.
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They also noted greater fatty acid uptake in the myocytes from diabetic rats and suggested that ketone-induced impairment of fatty acid oxidation might be responsible for the greater triglyceride storage in the heart with diabetes ().
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Little is known about the effect of HF on myocardial lactate metabolism.
Following 3 mo of etomoxir treatment (80 mg), there was an improvement in LV ejection fraction, cardiac output at peak exercise, and clinical status (); however, this trial was not able to assess the long-term safety of etomoxir treatment.
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The publication also discloses preparation of ranolazine free base by treating its dihydrochloride salt with liquor ammonia, in a mixture of water and acetone.
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It is unlikely, however, that alternative technologies will displace the need for the conventional class and its development.
OConnor and his team became aware of this when they noted that moving the spleen affected mesothelial cells that lined it, and the signals modulating the inflammatory response were lost.
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Heart failure is not a disease but rather a complex clinical syndrome that is generally defined as an impaired ability of the ventricle to fill with and eject blood ().
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Some of the less common or rare side effects include chest pain or discomfort, lightheadedness, dizziness, or fainting, shortness of breath, slow or irregular heartbeat, unusual tiredness, change in taste, increased sensitivity of the skin to sunlight, loss of taste and severe sunburn.
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