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It is prudent to advise all women of child-bearing age to avoid getting pregnant until TB treatment is completed.

Oral vitamin K 1 is the treatment of choice unless very rapid reversal of anticoagulation is critical, when vitamin K 1 can be administered by slow intravenous infusion (5 to 10 mg over 30 minutes).

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To verify that antimicrobial susceptibility test results are accurate, at least one control organism should be included with each test or new set of testing conditions.

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When used as an initial test replacing smear microscopy (15 studies, 7517 participants), Xpert achieved a pooled sensitivity of 88% (95% CrI 83% to 92%) and pooled specificity of 98% (95% CrI 97% to 99%).

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Patients with suspected TB IRIS should be evaluated for other opportunistic infections, poor adherence or inadequate absorption of TB drugs, and importantly, for drug-resistant TB, which can be clinically indistinguishable and is a significant cause of clinical deterioration in patients on TB treatment in regions where rifampin resistance is a growing problem.

Rifabutin is effective, but is not included on the WHO list because for most developing countries, it is impractically expensive.

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Tuberculosis usually affects the lungs, but the disease may spread to other organs, including the gastrointestinal and genitourinary tracts, bones, joints, nervous system, lymph nodes, and skin.

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Until the development of Xpert, smear microscopy had been the sole method used for TB diagnosis in most laboratories in developing countries, where over 95% of TB-related deaths occur.

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As there is no coagulation assay available for any NOAC that provides information on effective anticoagulation over the past 3 weeks, it is mandatory to explicitly ask the patient about adherence over the last weeks and to document the answer in their file.

Section 7, Drug Interactions, that may necessitate regular measurements of the serum concentrations of the drugs in question.

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Significant drug interactions were not reported in any of the trials, and details concerning hepatic toxicity were not provided in the first three trials.

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The symptoms of TB commonly resolve within a few weeks of starting TB treatment and many patients then lose motivation to continue taking their medication.

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Wheat et al studied the long term effect of rifampicin on nasal carriage of coagulase positive staphylococci and claimed oral rifampicin at a dose of 600 mg daily for 7-10 days cleared the organism for 3 months in 80% of cases.

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Fulminant hepatitis can occur in the course of TB treatment, but is fortunately rare; emergency liver transplantation may be necessary and deaths do occur.

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As mentioned, a single Xpert run will provide both detection of TB and detection of rifampicin resistance.

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Avoiding diabetic tablets in the period of TB treatment were not suggested by ortho physician even after we raised the confusions Another issue is its very difficult to find a TB specialist except in government hospitals.

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