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In fact, it has been stated that a high recombination rate could be selected when several mutations (present in different members of the population) are needed for adaptation ().

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For example, a less severely affected family member who would not meet clinical criteria for AGS but who has the same Jagged1 mutation as a severely affected family member is considered to have AGS.

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In general, men are more severely affected while female heterozygotes may exhibit a milder phenotype in families with an X-linked dominant inheritance.

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Telenti AP, Imboden P, Marchesi F, Lowrie D, Cole S, Colston MJ, Detection of rifampin-resistance mutations in Mycobacterium tuberculosis.

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Additionally, given that the prevalence of lower than expected drug levels was not known for patients with adequate response to anti-TB therapy, the overall contribution of pharmacotherapy to the cause of slow response in this cohort cannot be fully assessed.

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In addition, rifampin therapy can be associated with a prominent increase in both direct and total bilirubin within a few weeks of starting therapy without evidence of liver injury.

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