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Hartling L, Abou-Setta A, Dursum S, Mousavi SS, Pasichnyk D, Newton AS: Antipsychotics in adults with schizophrenia: comparative effectiveness of first-generation versus second-generation medications.

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In response to implementation challenges identified following the approval of the Clozapine REMS Program, the FDA announced, in November 2015, that the deadlines for certification of prescribers and pharmacies would be extended to help ensure that health care professionals had sufficient time to complete certification and to ensure patient access to clozapine was maintained.

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As in phase 1, there was again a high rate (74 percent) of patients who stopped taking their medication for any reason.

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It is required that the patient, physician, and pharmacy be registered with a clozapine manufacturer registry and report white blood counts (WBC) and absolute neutrophil counts (ANC) weekly during the first 6 months of therapy, every 2 weeks during the second 6 months of therapy, and monthly after 1 year of therapy.

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Human Rights Committee A group of people who come together within an agency to review situations in which a person's rights are being restricted and to ensure that all possible steps are being taken to remove and reduce restrictions.

Objective outcomes such as laboratory measures or death are unlikely to have been much affected by problems of blinding.

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