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Compared with cyclophosphamide-vincristine-doxorubicin-dexamethasone, cyclophosphamide-thalidomide-dexamethasone was associated with more constipation and somnolence, but a lower incidence of cytopenias.

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Consolidation using high-dose chemotherapy with autologous or allogeneic hematopoietic stem cell support has been applied to patients with advanced-stage peripheral T-cell lymphoma after induction therapy with CHOP-based regimens and after response to reinduction therapy at first relapse.

Flores-Suarez randomized 10 patients with class IV or V nephritis to either MMF up to 2 g daily or monthly intravenous cyclophosphamide ().

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The symptoms associated with hypersensitivity reactions reported in the previously untreated patients were urticaria, pruritus, flushing of the face, diarrhea associated with Oxaliplatin infusion, shortness of breath, bronchospasm, diaphoresis, chest pains, hypotension, disorientation and syncope.

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High doses are required for direct effects on tumor cells which results in immunosuppression.

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They could have clinically measurable or unmeasurable (but able to be evaluated) disease.

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Anecdotal reports suggest using aggressive chemotherapy for Burkitt or lymphoblastic lymphoma, followed by stem cell transplant consolidation in responding patients, when feasible.

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The detection of donor-directed, HLA-specific alloantibodies in recipients of unrelated hematopoietic cell transplantation is predictive of graft failure.

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The pattern of positive and negative results obtained with an ENA panel is evaluated in conjunction with a person's clinical findings.

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Total number of T cell was analyzed in ( a) patients treated with oncolytic adenovirus only and ( b) patients treated with oral CP together with the virus.

Although these abnormalities are mild among the irradiated patients (overall IQ fall of approximately 10 points), those who have received higher doses at a young age may have significant learning difficulties.

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Secondary endpoints were overall response, progression-free survival, overall survival, toxicity of the regimen and the ability to harvest peripheral blood stem cells (PBSCs) at the end of 4 cycles of therapy.

Does Cyclophosphamide Still Have a Role in the Treatment of Severe Inflammatory Eye Disease?

Survivors with a history of neuroendocrine or abdominal radiation therapy had an increased risk of spontaneous abortion.

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Cellular depletion of GSH content was correlated with an increase in 4-OHCP-induced cardiac cell toxicity and acrolein induced cytotoxicity in pulmonary artery endothelial cells.

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Fingolimod: Immunosuppressants may enhance the immunosuppressive effect of Fingolimod.

For invasive breast cancer, studies indicate that lumpectomy or partial mastectomy combined with radiation therapy works as well as a modified radical mastectomy.

Lymphoma resulted in the highest cumulative incidence of late-occurring intestinal obstruction requiring surgery (7.

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Some animals with atopic dermatitis may have a genetic predisposition that leads to excessive production of reaginic (IgE) antibodies.

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From the Department of Medicine, Emory University, Atlanta (W.

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Azathioprine is less toxic than cyclophosphamide, as azathioprine does not induce bladder injury and has less oncogenic potential.

Seven of the 10 patients had already experienced episodes of nephritis requiring steroids plus cyclophosphamide or mycophenolate mofetil.

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Glomerular lesions occur primarily through immune-mediated pathways rather than through direct drug toxicity.

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Intravenous pulse administration of cyclophosphamide is often used in the treatment of pemphigus.

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The first signal is delivered by the cytokines IL-4 or IL-13 released by T H2 cells, which target the C ε gene for switch recombination.

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There was no efficacy advantage of AC over CMF, possibly because of the shorter duration of treatment and the elimination of both 5-fluorouracil and methotrexate from the combination, and over the ensuing 30 years, CMF and AC became references for the development of newer, more effective chemotherapy regimens on both sides of the Atlantic.

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This was probably due to the low exposure to the cytotoxic metabolite 4-OHCP and consequent low immunosuppressive effect.

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