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Common side effects include influenza-like symptoms (fever, chills, sweating, and myalgias), headache, fatigue, dizziness, nausea and vomiting, diarrhea, anorexia, abdominal pain, depression, irritability, and injection site reaction.
Compared with cyclophosphamide-vincristine-doxorubicin-dexamethasone, cyclophosphamide-thalidomide-dexamethasone was associated with more constipation and somnolence, but a lower incidence of cytopenias.
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Emerging data indicate that females treated with low-dose, involved-field radiation also exhibit excess breast cancer risk.
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Consolidation using high-dose chemotherapy with autologous or allogeneic hematopoietic stem cell support has been applied to patients with advanced-stage peripheral T-cell lymphoma after induction therapy with CHOP-based regimens and after response to reinduction therapy at first relapse.
Flores-Suarez randomized 10 patients with class IV or V nephritis to either MMF up to 2 g daily or monthly intravenous cyclophosphamide ().
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Compared with the group not receiving selenium, those receiving selenium had a smaller reduction in white blood cell count and fewer chemotherapy side effects such as nausea, hair loss, weakness, and loss of appetite.
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Animals with immune-mediated thrombocytopenia that show only petechial and ecchymotic hemorrhages, with no significant blood loss and megakaryocytes in the marrow, may be treated initially with glucocorticoids.
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In the case of GPA, the change was triggered by evidence that Wegener was a member of the Nazi party before and during World War II.
The symptoms associated with hypersensitivity reactions reported in the previously untreated patients were urticaria, pruritus, flushing of the face, diarrhea associated with Oxaliplatin infusion, shortness of breath, bronchospasm, diaphoresis, chest pains, hypotension, disorientation and syncope.
Methods and observations that may be used to detect the presence or release of an HCS-covered hazardous drug in the work area (such as monitoring conducted by the employer, continuous monitoring devices, visual appearance or odor of covered HD's being released, etc.
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SE) changes in these values, adjusted with the use of Huber estimation, are shown in Table 2 Change in Values from Baseline to Month 12.
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High doses are required for direct effects on tumor cells which results in immunosuppression.
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They could have clinically measurable or unmeasurable (but able to be evaluated) disease.
Rituximab in severe, treatment-refractory interstitial lung disease.
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Anecdotal reports suggest using aggressive chemotherapy for Burkitt or lymphoblastic lymphoma, followed by stem cell transplant consolidation in responding patients, when feasible.
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Non-Hodgkin's lymphoma of the gastrointestinal tract: a population-based analysis of incidence, geographic distribution, clinicopathologic presentation features, and prognosis.
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The detection of donor-directed, HLA-specific alloantibodies in recipients of unrelated hematopoietic cell transplantation is predictive of graft failure.
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The pattern of positive and negative results obtained with an ENA panel is evaluated in conjunction with a person's clinical findings.
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Protective effect of simvastatin in the cyclophosphamide-induced hemorrhagic cystitis in rats.
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Lupus and other autoimmune disorders may lower the number of leukocytes in the body below a normal level.
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Total number of T cell was analyzed in ( a) patients treated with oncolytic adenovirus only and ( b) patients treated with oral CP together with the virus.
Although these abnormalities are mild among the irradiated patients (overall IQ fall of approximately 10 points), those who have received higher doses at a young age may have significant learning difficulties.
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Secondary endpoints were overall response, progression-free survival, overall survival, toxicity of the regimen and the ability to harvest peripheral blood stem cells (PBSCs) at the end of 4 cycles of therapy.
Does Cyclophosphamide Still Have a Role in the Treatment of Severe Inflammatory Eye Disease?
Survivors with a history of neuroendocrine or abdominal radiation therapy had an increased risk of spontaneous abortion.
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Cellular depletion of GSH content was correlated with an increase in 4-OHCP-induced cardiac cell toxicity and acrolein induced cytotoxicity in pulmonary artery endothelial cells.
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Risk was directly proportional to dose.
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Identify physical and emotional factors that can cause fatigue.
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Fingolimod: Immunosuppressants may enhance the immunosuppressive effect of Fingolimod.
For invasive breast cancer, studies indicate that lumpectomy or partial mastectomy combined with radiation therapy works as well as a modified radical mastectomy.
Lymphoma resulted in the highest cumulative incidence of late-occurring intestinal obstruction requiring surgery (7.
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Relapse-free survival was defined as time to occurrence of a local, regional, or distant recurrence, or disease-related death.
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Quantitative CT of Fibrotic Interstitial Lung Disease.
Risk of bone marrow suppression, hypersensitivity reactions, infertility, pulmonary toxicities, and secondary malignancies.
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Some animals with atopic dermatitis may have a genetic predisposition that leads to excessive production of reaginic (IgE) antibodies.
Angela Esposito, Lucia Gelao, Carmen Criscitiello, Giuseppe Curigliano.
From the Department of Medicine, Emory University, Atlanta (W.
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Azathioprine is less toxic than cyclophosphamide, as azathioprine does not induce bladder injury and has less oncogenic potential.
Seven of the 10 patients had already experienced episodes of nephritis requiring steroids plus cyclophosphamide or mycophenolate mofetil.
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See Drug Reference for a full list of side effects.
Glomerular lesions occur primarily through immune-mediated pathways rather than through direct drug toxicity.
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Intravenous pulse administration of cyclophosphamide is often used in the treatment of pemphigus.
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Pemphigus foliaceus is the most common of these diseases, occurring more often in dogs than in cats and horses.
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The first signal is delivered by the cytokines IL-4 or IL-13 released by T H2 cells, which target the C ε gene for switch recombination.
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Cyclophosphamide interferes with the growth of cancer cells and slows their growth and spread in the body.
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There was no efficacy advantage of AC over CMF, possibly because of the shorter duration of treatment and the elimination of both 5-fluorouracil and methotrexate from the combination, and over the ensuing 30 years, CMF and AC became references for the development of newer, more effective chemotherapy regimens on both sides of the Atlantic.
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This was probably due to the low exposure to the cytotoxic metabolite 4-OHCP and consequent low immunosuppressive effect.
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Astragalus injection as adjuvant therapy for 68 cases with congestive heart failure.
While you are using cyclophosphamide, it is important that you drink extra fluids so that you will pass more urine.
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