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Figure 1: Flowchart of the potential therapeutic options after PSA progression following hormonal therapy in metastatic patients.
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survival rates were similar among patients receiving high doses of bicalutamide
This difference in effectiveness in men and women may be related to the fact that NSAAs like flutamide significantly increase androgen levels in men, which counteracts their antiandrogen efficacy, but do not increase androgen levels in women.
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The presence of residual androgens and persistent activation of the AR signaling axis in CRPC suggest that a multi-targeted treatment approach to ablate all contributions to AR signaling within the prostate tumor will be required for optimal anti-tumor efficacy.
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