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Using CA9, a carbonic anhydrase, as a surrogate marker for tumor hypoxia, we showed by immunohistochemistry (IHC) that HIF-1a expression within these two brain tumor areas may be driven by different mechanisms (possibly leading to distinct cellular responses): Hypoxic cells within the pseudopalisades exhibited staining for HIF-1a and CA9, whereas all the invading HIF-1a positive glioma cells in the BAT were negative for CA9.
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