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The objective of this study was to assess the efficacy and safety of oral thiocolchicoside (TC), a natural glycoside as compared to an adrenergic alpha 2 agonist tizanidine (TZ) in the Indian patients with LBP accompanied by muscle spasm.
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Thiocolchicoside was screened in vitro in different concentrations for UV-Vis-induced phototoxic effects in a photohemolysis test, in the presence and absence of different radical scavengers, singlet oxygen and superoxide radical quenchers.
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The cumulative occurrence of resistance mutations in the HIV-1 protease gene is associated with failure of salvage therapy with ritonavir and saquinavir in protease inhibitor-experienced patients1.
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Physicians should maintain a healthy skepticism while awaiting clarification of the optimal use of protease inhibitors, and whenever possible, specialists in the care of patients with AIDS should be involved in treatment decisions.
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Trellu M, Filali-Ansary A, Françon D, Adam R, Lluel P, Dubruc C, Thénot JP: New metabolic and pharmacokinetic characteristics of thiocolchicoside and its active metabolite in healthy humans.
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