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Does methotrexate cause loss of appetite? ∎ Methotrexate occasionally causes loss of appetite, indigestion, nausea, or vomiting around the day you take the medicine. ∎ You will need to take folic acid (a vitamin) daily while on methotrexate. Folic acid helps prevent red blood cell abnormalities and reduces side effects.
Do the side effects of methotrexate ever go away? Methotrexate users may develop other issues, but many can be monitored by regular blood tests. These side effects often go away if you stop taking the drug temporarily (which should only be done under a doctor's supervision).
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