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Use a spray bottle to periodically mist the skin, or apply cool, wet cloths.

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Tcells (cells of immune system) in the inner layer of the intestine and blood secrete inflammatory cytokines (constituents of immune system), which lead to inflammatory cascade and the flare up of the disease.

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Several hypotheses may explain this lack of adequate clinical response in this group: incomplete drug effect as a result of insufficient dosing, end-stage lacrimal gland disease as a consequence of complete destruction or conjunctival scarring, or individual risk factors and ocular surface-specific immunologic mechanisms that are yet unknown.

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