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Barrett-Connor E, Wingard DL, Criqui MH "Postmenopausal estrogen use and heart disease risk factors in the 1980s.
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Effects of estrogen dose and smoking on lipid and lipoprotein levels in postmenopausal women.
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Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, Estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites, estrone and estriol, at the receptor level.
Health Initiative to differentiate between women starting hormone therapy within five years of menopause or later, the risk of coronary heart disease was non-significantly increased, and an additional non-significant difference owing to timing of starting hormone therapy.
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