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How far apart should Sinemet be taken? Dosage is best initiated with one tablet of SINEMET 25-100 three times a day. This dosage schedule provides 75 mg of carbidopa per day. Dosage may be increased by one tablet every day or every other day, as necessary, until a dosage of eight tablets of SINEMET 25-100 a day is reached.
How many hours apart should you take Sinemet? Administer at regular intervals as prescribed to provide therapeutic coverage and lessen "wearing off" time. Extended-release tablets (e.g., Sinemet CR): Do not crush or chew; swallow intact. Dosing intervals range from 4 to 8 hours while awake and are individualized to the patient.
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