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I have suffered from obsessive compulsive disorder and generalized anxiety for years. Anxiety, depression and bipolar run in my family and for some reason I have been hesitant to get on medication. I have a very stressful job and am currently in graduate school...and finally decided enough is enough. I have been on Zoloft for 2 days and I can already tell a difference. The tightness in my chest is gone from chronic stress and I feel happier. I am kicking myself for not getting on this medication earlier.

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Antidepressants may have serious (potentially fatal) drug interactions with certain other types of medications, so patients should have a careful discussion with their physician before taking antidepressants.

In 2005, the Food and Drug Administration (FDA) added a black box warning regarding pediatric suicidality to all antidepressants, including sertraline.

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Like the popular brand, sertraline is an antidepressant included in a group of drugs known as selective serotonin reuptake inhibitors (SSRIs).

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It is used to treat low mood (depression).

SSRIs, including Sertraline, and most tricyclic antidepressant drugs effective in the treatment of major depressive disorder inhibit the biochemical activity of the drug metabolizing isozyme cytochrome P450 2D6 (debrisoquin hydroxylase), and, thus, may increase the plasma concentrations of co-administered drugs that are metabolized by P450 2D6.

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CBC) monitored frequently during the first few months of therapy and discontinuation of ABILIFY (aripiprazole) should be considered at the first sign of a clinically significant decline in WBC count in the absence of other causative factors.

When alcohol is combined with Zoloft, severity of the side effects such as slow reflexes, drowsiness, and clouded judgment may increase suddenly.

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Anyone considering the use of sertraline hydrochloride or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need.

Patients receiving Sertraline hydrochloride experienced a mean reduction of approximately 4 points on the YBOCS total score which was significantly greater than the mean reduction of 2 points in placebo-treated patients.

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In over 600 pediatric patients treated with sertraline, the overall profile of adverse events was generally similar to that seen in adult studies.

In a placebo-controlled, double-blind, randomized study of the comparative abuse liability of sertraline hydrochloride, alprazolam, and d-amphetamine in humans, sertraline hydrochloride did not produce the positive subjective effects indicative of abuse potential, such as euphoria or drug liking, that were observed with the other two drugs.

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