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How much indomethacin can I take at once? Adult dosage (ages 18 years and older) Immediate-release capsule: Indomethacin is usually dosed 2 to 3 times per day and starts at a dose of 25 mg. Your doctor may increase your dose by 25 or 50 mg per day. The maximum dose is 200 mg per day. Extended-release capsule: The dose is 75 mg once or twice per day.
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