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Is mesalamine over the counter? Over-the-counter (OTC) Drugs. Over-the-counter drugs, which don't require a prescription, can be very helpful. Medicines for diarrhea and the pain reliever acetaminophen (Tylenol) are commonly used to help ease symptoms. Some OTC pain relievers, such as ibuprofen (Advil, Motrin), can make you feel worse, though.
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