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What is the best antihistamine for urticaria? Fexofenadine (Allegra), loratadine (Claritin), and cetirizine (Zyrtec) These antihistamines typically come in 12- or 24-hour formulas to provide extended relief. They're also less likely to cause drowsiness than diphenhydramine.
What is the best treatment for urticaria? Antihistamines are the best, first-line treatment for hives.1 These drugs work by suppressing histamine, a chemical produced by the immune system that instigates the symptoms of allergy. For most types of urticaria, an over-the-counter (OTC) antihistamine may provide ample relief.

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