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The Iressa Pan-Asia Study (IPASS) was the first phase III randomized trial that demonstrated superior outcome with first-line EGFR-TKI treatment in patients with EGFR-mutant NSCLC when compared with platinum-based chemotherapy in a retrospective subgroup analysis ().
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Limitation of Use: Safety and efficacy of IRESSA have not been established in patients whose tumors have EGFR mutations other than exon 19 deletions or exon 21 (L858R) substitution mutations.
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Class comparison analysis of control (KRAS-WT, KRAS-EV) versus KRAS mutant (KRAS-G12D, KRAS-G13D) samples demonstrated that both mutations caused widespread changes in the transcriptome of MCF10A cells.
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Two weeks after treatment initiation, adenocarcinomas had almost completely disappeared in both groups (Fig.
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Furthermore, although gefitinib was withdrawn from the market in the United States in 2005, approximately 250 patients with NSCLC were still alive as of 2011 in the AstraZeneca Iressa Expanded Access Program (NCT00034879), demonstrating that long-term survival of patients with NSCLC is possible while they receive EGFR TKIs.
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