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MPA also interferes with the benefits of estrogens on coronary vasospasm and exercise-induced myocardial ischemia.

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Aside from the need for disclosure to the patients considering enrollment in the study, what assurance does Langer and her oncologist colleague have of the likelihood of any benefit.

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CDC, through close collaboration with WHO, has contributed substantially during the last 15 years to creation of WHO's global family planning guidance, which includes four documents: the medical eligibility criteria for contraceptive use, the selected practice recommendations for contraceptive use, a decision-making tool for clients and providers, and a global family planning handbook.

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