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Selecting a control group of women who had undergone biopsies but were not found to have EH would not be an acceptable alternative as they would not be expected to have hormone medication histories that would be representative of the general population from whence the cases arose.

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HRT use in selected breast cancer survivors with severe climacteric symptoms is suggested.

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Aside from the need for disclosure to the patients considering enrollment in the study, what assurance does Langer and her oncologist colleague have of the likelihood of any benefit.

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CDC, through close collaboration with WHO, has contributed substantially during the last 15 years to creation of WHO's global family planning guidance, which includes four documents: the medical eligibility criteria for contraceptive use, the selected practice recommendations for contraceptive use, a decision-making tool for clients and providers, and a global family planning handbook.

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