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Which antipsychotics cause the most sedation? A study by Richelson and Souder 7 of the binding profiles of antipsychotic medications found that olanzapine has the highest affinity for the histamine H 1 receptors, followed by clozapine (Figure 1). This may explain why olanzapine has a relatively large sedative effect even though it is a high-potency medication.
What causes tardive dyskinesia? Tardive dyskinesia refers to unintended facial movements usually caused by antipsychotic medication. Tardive dyskinesia is often a side effect of antipsychotic drugs. These drugs work to block dopamine, which is a chemical in the brain that helps control muscle movement.
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