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Formal use of the bark to treat malaria was established in the mid-1800s when the British began the worldwide cultivation of the plant in order to assure the continuing availability because the plant was in danger of extinction in some regions because of the harvesting of wild populations.

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No antimalarial drug is 100% protective and must be combined with the use of personal protective measures, (i.

In general, more details are needed, as worsening kidney problems from hydration or gall bladder problems from not eating could complicate the picture, even if the malaria is treated.

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