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What medications are not safe during pregnancy? What medicines should you avoid during pregnancy? Bismuth subsalicylate (such as Pepto-Bismol). Phenylephrine or pseudoephedrine, which are decongestants. Cough and cold medicines that contain guaifenesin. Pain medicines like aspirin and ibuprofen (such as Advil and Motrin) and naproxen (such as Aleve).
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