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What's the difference between valacyclovir and acyclovir? Acyclovir and valacyclovir are identical drugs that treat herpes simplex viruses. Both drugs treat HSV-1, HSV-2, and herpes zoster viruses. Valacyclovir, on the other hand, can be taken up to 2 or 3 times daily. Despite their differences in dosing, acyclovir and valacyclovir have little difference in effectiveness.
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