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Desloratadine oral solution is indicated for the symptomatic relief of pruritus, reduction in the number of hives, and size of hives, in patients with chronic idiopathic urticaria 6 months of age and older.
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Further intervention depends on severity of reaction and affected organ system(s), but the guidelines recommend the injection of epinephrine and placing the patient in a supine position (or position of comfort if dyspneic or vomiting) with the legs elevated.
This problem will improve only when the use of the nasal drops or spray is discontinued.
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These compounds are structurally related to the ethylenediamines and the ethanolamines, and produce significant adverse effects.
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Gender: Female subjects treated for 14 days with Clarinex Tablets had 10% and 3% higher desloratadine C max and AUC values, respectively, compared with male subjects.
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Chronic Idiopathic Urticaria: In multiple-dose, placebo-controlled trials of chronic idiopathic urticaria, 211 patients ages 12 years or older received Desloratadine Tablets and 205 received placebo.
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This was also the case in this study, with no differences in the safety profile of desloratadine between poor metabolizers and other subjects.
Anaphylaxis: a review of causes and mechanisms.
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Randomized placebo-controlled trial comparing desloratadine and montelukast in monotherapy and desloratadine plus montelukast in combined therapy for chronic idiopathic urticaria.
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