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The primary efficacy end point was change in the YMRS total score from baseline to day 43, analyzed using a mixed-model for repeated measures (MMRM) approach.

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Although a single fixed dose haloperidol arm was included as a comparative treatment in one of the three trials, this single haloperidol dose group was inadequate to provide a reliable and valid comparison of SEROQUEL and haloperidol.

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Future analyses may include an evaluation of factors that may have predicted relapse in each patient group, including treatment noncompliance, baseline remission, and baseline symptom severity.

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Residents were excluded if they filled a prescription for both conventional and atypical antipsychotics on the index date and if they had a pre-existing diagnosis for cancer, schizophrenia, or bipolar disorder as these residents probably received antipsychotics for reasons other than behavioural problems related to dementia (fig 1).

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Excluding patients who discontinued because of relapse, no differences were observed in other reasons for discontinuation between the treatment groups.

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Primary endpoint: change from randomization to Week 8 in MADRS total score.

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