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Subset analyses of the antiepileptic efficacy of Topiramate tablets in these studies showed no differences as a function of gender, race, age, baseline seizure rate, or concomitant AED.

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While many anticonvulsants have been associated with apoptosis in young animals, animal experiments have found that topiramate is the only anticonvulsant that does not induce apoptosis in young animals at doses needed to produce an anticonvulsant effect.

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Drug names: bupropion (Wellbutrin), carbamazepine (Tegretol and others), carbidopa-levodopa (Sinemet and others), celecoxib (Celebrex), citalopram (Celexa), clozapine (Clozaril and others), divalproex sodium (Depakote), fluoxetine (Prozac), furosemide (Lasix and others), lamotrigine (Lamictal), levothyroxine (Synthroid and others), lithium carbonate (Eskalith and others), medroxyprogesterone acetate (Amen and others), olanzapine (Zyprexa), oxybutynin (Ditropan and others), phenobarbital (Donnatal and others), risperidone (Risperdal), topiramate (Topamax), valproic acid (Depakene), venlafaxine (Effexor), zolpidem (Ambien).

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Acknowledgment: Grants from the Swedish Medical Research Council (K97-17X-12225-01A) and Janssen-Cilag supported this study.

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Be sure to mention any of the following: acetazolamide (Diamox); amitriptyline; antidepressants; antihistamines; dichlorphenamide (Daranide); digoxin (Lanoxin, Digitek); hydrochlorothiazide (Microzide, Oretic); ipratropium (Atrovent); iron; isoniazid (INH, Nydrazid); lithium (Eskalith, Lithobid); medications for anxiety, irritable bowel disease, mental illness, motion sickness, Parkinson's disease, ulcers, or urinary problems; metformin (Glucophage); methazolamide; hormonal contraceptives (birth control pills, patches, rings, implants, or injections); other medications for seizures such as carbamazepine (Tegretol) and phenytoin (Dilantin, Phenytek); pioglitazone (Actos); risperidone (Risperdal); salicylate pain relievers such as aspirin, choline magnesium trisalicylate (Trisalate), choline salicylate (Arthropan), diflunisal (Dolobid), magnesium salicylate (Doan's, others), and salsalate (Argesic, Disalcid, Salgesic); sedatives; sleeping pills; tranquilizers; valproic acid (Depakene, Depakote); and zonisamide (Zonegran).

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