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Data Sources: Data were obtained via the MEDLINE database in an English-language search spanning the period 1965 to May 2002 and using the search terms bupropion, bupropion SR, and antidepressants, as well as from the manufacturer's bupropion databases.
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The drug treatment group showed a significant decline in analgesic intake per week.
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Low-quality evidence showed no difference in response (1 trial; escitalopram) () or remission (2 trials; citalopram, escitalopram, or sertraline) (, ) for SGAs compared with interpersonal therapy for patients with MDD after 12 weeks of treatment.
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In addition to decreasing the frequency of panic attacks by about 80% and decreasing general anxiety, sertraline resulted in improvement of quality of life on most parameters, in contrast with the placebo, which did not improve the quality of life as much even among the patients who apparently responded to it.
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Indeed, paroxetine has considerable potency for muscarinic receptors, allowing it to affect these receptors at the blood levels expected during treatment ().
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Comments: Newborns should be monitored if the maternal use of this drug continues into the later stages of pregnancy, particularly, the third trimester.
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Untoward events associated with this exposure were recorded by clinical investigators using terminology of their own choosing.
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Petechiae, purpura, ecchymosis, increased bleeding times, epistaxis and gastrointestinal hemorrhage have been reported.
Also, families and caregivers should be advised to closely observe these patients and communicate with the prescriber.
Importance of informing patients that if they receive diuretics, or are otherwise volume-depleted, or are elderly, that they may be at greater risk of developing hyponatremia during sertraline therapy.
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