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The radiation had been done with no apparent results and he and his wife decided that rather than go through the misery of chemo they would just live as long as possible and forget it.

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In fact, more than 50% of all patients with craniopharyngioma are under the age of 18 years.

Buchsbaum DJ, Bonner JA, Grizzle WE, Stackhouse MA, Carpenter M, Hicklin DJ, Bohlen P, Raisch KP (2002) Treatment of pancreatic cancer xenografts with Erbitux (IMC-C225) anti-EGFR antibody, gemcitabine, and radiation.

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The first treatment children with high risk disease have is chemotherapy.

Oral etoposide is active against a wide range of tumours but enthusiasm for its use has been limited by concerns over toxicity.

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Erlotinib (Tarceva) is in the same medication class as gefitinib.

Depending on where the cancer is located and how large in size it is doctors may decide to perform one of two types of surgeries on the breast.

Topical therapy with modern wound dressings is useful to minimize pain and the risk of secondary infections.

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This article will focus on the one-third of the cancer patient population that is actively receiving cytotoxic chemotherapy on an outpatient basis who require ongoing analgesic therapy to control their pain.

The legs are most commonly affected but other parts of the skin and mucous membranes may also be involved.

Usually avoid combinations; use it only under special circumstances.

One prior study involving healthy volunteers found the use of Prilosec lowered blood concentrations of Tarceva by 61 percent.

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However, the recent FDA approval of ceritinib for patients with ALK-positive NSCLC who experience disease progression with crizotinib is a potentially practice-changing event.

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The paradigm of molecularly targeted therapy in oncology depends critically on a validated test to provide a uniform platform for detecting the molecular alteration in question.

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Examples of CYP2D6 substrates can be found in antidepressants (amitriptyline, citalopram, clomipramine, desipramine, doxepin, fluvoxamine, imipramine, maprotiline, mianserin, nortriptyline, fluoxetine, paroxetine), antipsychotics (chlorpromazine, clozapine, haloperidol, perphenazine, risperidone, thioridazine, zuclopenthixol), antiarrhythmics (flecainide, mexiletine, propafenone), beta-blockers (carvedilol, metoprolol, yohimbine, timolol), opioid analgesics (codeine, dihydrocodeine, morphine, tramadol), anticancer agents (debrisoquine, gefitinib, sparteine, tamoxifen), and assorted other drugs (atomoxetine, dextromethorphan, perhexilline, tolterodine).

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Patients undergoing some weeks of treatment usually experience fatigue caused by the healthy tissue repairing itself and aside from this there can be no side effects at all.

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To date, unlike the situation in colorectal cancer, mutation of the v-Ki- Ras-2 Kirsten rat sarcoma viral oncogene homolog (KRAS) has an inconclusive role in NSCLC and should not be used to exclude patients from anti-EGFR therapy.

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No benefit as far as overall survival is concerned.

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Intralesional injection of the talimogene laherparepvec (T-VEC) is a new category 1 option for patients with stage III melanoma in transit; a footnote mentions its efficacy as well in stages IIIB, IIIC, and IV M1a disease, especially in treatment-naive patients.

Toxicities were similar to adults.

Since these frequencies are very similar to the frequency of EGFR mutations observed in our series of BAC, we suggest that about one fourth of BACs may respond to EGFR TK inhibitors because of mutations affecting the gene.

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None of our patients experienced interstitial pulmonary fibrosis, a known and serious side-effect of EGFR TKIs ().

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These findings imply that the EGFR-TKI gefitinib and CPT-11 will be effective against colorectal tumor cells that express high levels of EGFR, and support clinical evaluation of gefitinib in combination with CPT-11, in the treatment of colorectal cancers.

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The later part of the 20th century also saw the development of targeted therapies like growth factor inhibitors like trastuzumab (Herceptin), gefitinib (Iressa), imatinib (Gleevec), and cetuximab (Erbitux).

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Rash and diarrhea, hallmark and dose-dependent side-effects of EGFR inhibitors, were not frequent in our patients.

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Medical record extraction and direct confirmation with the treating physician identified that in all cases the treating physician offered the dose of 25 mg daily of erlotinib due to its supposed equivalence to gefitinib 250 mg daily and that patients were informed the 25 mg dose was not the standard dose of erlotinib for NSCLC.

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