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For patients with BD depression with psychotic features, an antipsychotic medication should be started.
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Renal creatinine clearance and kinetic data of clozapine and metabolites measured during four 2 h intervals in 15 psychotic patients.
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Table 3 provides guidelines for managing Clozapine treatment and ANC monitoring in patients with BEN.
The placebo and nocebo effects can present clinicians with an ethical dilemma.
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Because of the risks with this medication, clozapine is available only through a special restricted distribution program.
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REMS Program to submit ANCs and provide authorization to receive clozapine.
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This concept is recognized by the majority of authors, although other authors only refer to synergy when there is an enhanced effect.
During the assessment, clinicians should check for medical consequences of substance use in order to facilitate diagnostic assessment, encourage patients to seek needed medical attention, and ensure an appropriate choice of psychiatric medications.
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Conley RB, Kelly DL, Lambert TJ, Love RC: Comparison of clozapine use in Maryland and in Victoria, Australia.
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These results suggest that plasma clozapine levels are correlated with clinical effects, although there is considerable variability in the response achieved at any given drug concentration.
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In contrast to more typical antipsychotic drugs, CLOZARIL therapy produces little or no prolactin elevation.
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Asking the client challenging questions such as why he is depressed is not therapeutic and may cause feelings of inadequacy and shame over not being able to answer.
CLOZAPINE) SHOULD BE RESERVED FOR USE IN (1) THE TREATMENT OF SEVERELY ILL PATIENTS WITH SCHIZOPHRENIA WHO FAIL TO SHOW AN ACCEPTABLE RESPONSE TO ADEQUATE COURSES OF STANDARD ANTIPSYCHOTIC DRUG TREATMENT, OR (2) FOR REDUCING THE RISK OF RECURRENT SUICIDAL BEHAVIOR IN PATIENTS WITH SCHIZOPHRENIA OR SCHIZOAFFECTIVE DISORDER WHO ARE JUDGED TO BE AT RISK OF REEXPERIENCING SUICIDAL BEHAVIOR.
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What are possible side effects of Clozapine?
The occurrence of agranulocytosis is a substantial hazard of the administration of clozapine, but this hazard can be reduced by monitoring the white-cell count.
Generally, patients with a history of clozapine-associated myocarditis or cardiomyopathy should not be rechallenged with Clozaril.
The use of clozapine is more problematic because of the risk of agranulocytosis as well as the anticholinergic, sedative, and orthostatic hypotensive adverse effects.
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Clozapine faced a few other significant market barriers, all associated with the required patient monitoring that may be reduced now that the monitoring requirements have been lowered.
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Minimally interacting with the client is not therapeutic and ignores the client's needs.
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However, its also been noted that light therapy can sometimes cause side effects, such as mania, in people with bipolar disorder.
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