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Table 3 provides guidelines for managing Clozapine treatment and ANC monitoring in patients with BEN.

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Conley RB, Kelly DL, Lambert TJ, Love RC: Comparison of clozapine use in Maryland and in Victoria, Australia.

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In contrast to more typical antipsychotic drugs, CLOZARIL therapy produces little or no prolactin elevation.

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The occurrence of agranulocytosis is a substantial hazard of the administration of clozapine, but this hazard can be reduced by monitoring the white-cell count.

Generally, patients with a history of clozapine-associated myocarditis or cardiomyopathy should not be rechallenged with Clozaril.

The use of clozapine is more problematic because of the risk of agranulocytosis as well as the anticholinergic, sedative, and orthostatic hypotensive adverse effects.

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Clozapine faced a few other significant market barriers, all associated with the required patient monitoring that may be reduced now that the monitoring requirements have been lowered.

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