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Although it has been eradicated from temperate zones, each year an increasing number of travelers from these areas are exposed to the risk of malaria while visiting tropical countries.
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Metabolism is almost exclusively via CYP pathways, primarily CYP3A4; other isozymes, including CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP2E1, are less influential in quinine metabolism.
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Your doctor might also want to test you for some other common diseases, such as bacterial infections, viral infections or even other parasites; the symptoms of malaria are quite non-specific and similar to lots of other infections, so if you tested positive for malaria your doctor might have focused on treating that and not looked for other potential co-infections.
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This book dives into the fascinating history of the use of quinine to treat malaria and how the disease impacted major world events over the centuries.
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McGready R, Brockman A, Cho T, Cho D, van Vugt M, Luxemburger C, Chongsuphajaisiddhi T, White NJ, Nosten F: Randomized comparison of mefloquine-artesunate versus quinine in the treatment of multidrug-resistant falciparum malaria in pregnancy.
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The trial was open label at each site, and none of the investigators or trialists, apart from for the trial statistician, had access to the summaries of treatment allocations.
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Consequently, a drug regimen consisting of atovaquone and azithromycin is now first-line treatment for mild-to-moderate disease and has been shown to be effective, especially when clindamycin and quinine fail.
The endpoint review committee identified 16 children (seven artesunate, nine quinine) in whom death was unlikely to be related to severe malaria.
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Urinary alkalizers (acetazolamide, sodium bicarbonate): Urinary alkalinizing agents may increase plasma quinine concentrations.
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Other causes include alcoholism, rheumatoid arthritis, systemic lupus erythematosus, amyloidosis, HIV infection, kidney failure, and certain vitamin deficiencies.
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Such findings and other available data suggest that malaria treatment policy in HIV infected populations can generally follow the standard practices.
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From February to August 1907, the workers at Xerém started to be given 50cg of quinine hydrochloride, produced by Merck, every three days, which yielded promising results.
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Kayumba PC, Risha PG, Shewiyo D, Msami A, Masuki G, Ameye D, Vergote G, Ntawukuliryayo JD, Remon JP, Vervaet C: The quality of essential antimicrobial and antimalarial drugs marketed in Rwanda and Tanzania: influence of tropical storage conditions on in vitro dissolution.
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SIDE EFFECTS: Mild headache, flushing, unusual sweating, nausea, ringing in the ears, decreased hearing, dizziness, blurred vision, and temporary changes in color vision may occur.
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Rectal dosage forms are also a good alternative to the peroral route for certain groups of patients who cannot easily swallow tablets or capsules: this can be in the case of children and the elderly, as well as in the cases where patients may be unconscious or vomiting.
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The information presented herein was accurate at the time of publication; however, factors that can change rapidly and from year to year (such as local weather conditions, mosquito vector density, and prevalence of infection) can markedly affect local malaria transmission patterns.
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Rockefeller Foundation conducted a large-scale experiment to test the feasibility of the strategy of "species eradication" in an endemic malaria vector.
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White NJ, Looareesuwan S, Warrell DA, Warrell MJ, Bunnag D, Harinasuta T: Quinine pharmacokinetics and toxicity in cerebral and uncomplicated Falciparum malaria.
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Other than the above information, there is no additional information relating to proper use, precautions, or side effects for these uses.
Its exact method of action is not well understood, but it seems to accumulate in the red blood cells that have been infected with malaria and as a result destroys the parasites.
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Caffeine is one of only two drugs that are present naturally or added to widely consumed foods (quinine is the other drug used in foods).
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Mefloquine is contraindicated for use by travelers with a known hypersensitivity to mefloquine or related compounds (such as quinine or quinidine) and in people with active depression, a recent history of depression, generalized anxiety disorder, psychosis, schizophrenia, other major psychiatric disorders, or seizures.
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Avoid use in patients with known QT-interval prolongation, patients taking other drugs known to prolong the QT interval, or those with conditions known to prolong the QT interval (eg, bradycardia, certain cardiac conditions, uncorrected hypokalemia).
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However, I understand how this may not be possible in your situation, but I would still recommend that you protect yourself from mosquitoes as much as possible, such as sleeping under a long-lasting insecticide treated bednet at night, keeping windows and doors screened or tightly shut and wearing long sleeved clothing.
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