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Los nuevos hallazgos, que aparecen en la edicin en lnea del 2 de julio de la revista Blood, podran llevar a mejores tratamientos para el sndrome mielodisplsico y los cnceres relacionados con el sndrome, sugirieron en un comunicado de prensa del Colegio de Medicina Albert Einstein de la Universidad de Yeshiva investigadores del colegio, en la ciudad de Nueva York.

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Pathologists (doctors who look at tissue under the microscope) and hematologists (doctors specializing in blood diseases) will analyze the bone marrow and determine which type of cell has become cancerous and whether the leukemia is acute or chronic.

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Now, most cases of CML can be controlled, and researchers have developed new medications to counter to the drug when it arises.

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Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment.

It is also not clear if this combination is better than treatment with other tyrosine kinase inhibitors (TKIs), such as dasatinib and nilotinib.

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In the adjuvant treatment of GIST trials (Gleevec; placebo), severe (NCI Grades 3 and above) lab abnormalities - decrease in hemoglobin (1%; 0%), and increase in liver enzymes (ALT) (3%; 0%) - and severe adverse reactions (NCI Grades 3 and above), including fatigue (2% to 1%), periorbital edema (1%; 0%), abdominal pain (3%; 1%), nausea (2%; 1%), diarrhea (3%; 1%), rash (3%; 0%) and vomiting (2%; 1%) were reported among patients receiving adjuvant treatment with Gleevec.

Although first-generation treatment achieved an extremely high response rate and a low relapse rate in CML patients, some patients do experience resistance or to imatinib.

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Analyses of blast-crisis CML cell lines that have acquired resistance to STI571 after prolonged culture in doses below the threshold for inhibition of growth have shown amplification of the BCR-ABL gene, increased expression of the BCR-ABL protein without amplification of the gene, and increased expression of the multidrug-resistance protein (MDR1).

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