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The guideline was circulated in draft form to the Update Committee, ASCO's Health Services Committee, ASH's Committee on Practice, ASH's Subcommittee on Quality of Care, and the ASCO Board of Directors and the ASH Executive Committee for review and approval.

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Renal function became stable in one patient by the fourth week of treatment (Patient 10; serum creatinine, 200 to 220 μmol per liter) and remained normal in all other patients (data not shown).

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Selecting an appropriate outcome measure is often driven by many considerations including the purpose of the study, the patient-reported endpoint required to address the study purpose, the content of the items in the questionnaire with regard to the study purpose, and the validity of the questionnaire.

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