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That said, taking short breaks (for example 2 days off your med every week) will have a huge benefit on the potential downregulation, with LDOPA this can be done, with dopamine agonists probably not due to the autoreceptors.
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The precise mechanism of action of pramipexole as a treatment for Parkinson's disease is unknown, although it is believed to be related to its ability to stimulate dopamine receptors in the striatum.
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Prior results do not guarantee or predict a similar outcome with respect to any future matter.
If you stop taking this drug for a long time and need to start taking it again, you may have to start taking it at a lower dose and slowly work up to the dose you were taking.
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Low levels of dopamine in the brain are know to cause Parkinson's disease.
Patients, ages 18 to 70, with a diagnosis of Bipolar II disorder, depressed (without psychotic features), will be randomized to double-blind treatment to receive either pramipexole (0.
You must talk with your healthcare provider for complete information about the risks and benefits of using pramipexole.
However, other side effects were more common in the dopamine agonist group, and patients treated with levodopa alone had slightly better control of movement.
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Since younger patients are likely to require dopaminergic therapy for longer time and are at increased risk for the development of levodopa complications, levodopa sparing strategies, such as the use of MAO inhibitors and DA agonists, are even more critical in this population ().
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Improvement in the total off-medication motor scores was approximately 26% and 22%, respectively, at three months in the high dose cohort.
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In another study (conducted within a different VA system), approximately 50% of patients with PD received the recommended annual screening for depression, and this increased to 75% if a movement disorder specialist was involved.
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Approximately 12% of 388 patients with early Parkinson's disease and treated with MIRAPEX tablets who participated in the double-blind, placebo-controlled trials discontinued treatment due to adverse events compared with 11% of 235 patients who received placebo.
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