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Uptitration as necessary, with or without hydrochlorothiazide, allowed the majority of patients to achieve BP control in a 44-week open-label extension treatment period to the COACH trial.
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In controlled clinical trials, clinically important changes in standard laboratory parameters were rarely associated with administration of olmesartan medoxomil-hydrochlorothiazide.
Hg increase in the weighted average SeSBP reduction achieved with up-titration of the starting ARB monotherapy dosage ().
Effect of Candesartan on Microalbuminuria and Albumin Excretion Rate in Diabetes: Three Randomized Trials.
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Because of the increased frequency of other autoimmune diseases in type 1 diabetes, screening for thyroid dysfunction, vitamin B 12 deficiency, and celiac disease should be considered based on signs and symptoms.
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In patients who did not achieve their BP goal with their initial dosage of combination therapy, uptitration led to further reductions in 24-hour, daytime and night-time BP.
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The most affected organs include the brain, kidney, heart and lungs, producing symptoms which may include confusion, drowsiness, chest pain and breathlessness.
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Substitute Azor for its individually titrated components for patients on amlodipine and olmesartan medoxomil.
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These formulations demonstrated higher olmesartan medoxomil dissolution percent at each quantity of carmellose calcium than the drug products of Embodiment 2 containing no carmellose calcium (formulations 7, 9, 10, 11, and 12).
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In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, co-administration of NSAIDs, including selective COX-2 inhibitors, with angiotensin II receptor antagonists, including olmesartan medoxomil, may result in deterioration of renal function, including possible acute renal failure.
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Although any chloride deficit is generally mild and usually does not require specific treatment except under extraordinary circumstances (as in liver disease or renal disease), chloride replacement may be required in the treatment of metabolic alkalosis.
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