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The rates of hyperprolactinaemia according to therapeutic drug classes were as follow: 31% were associated with neuroleptics, 28% with neuroleptic-like drugs, 26% with antidepressants, 5% with H2-receptor antagonists, and 10% with other drugs ().

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In conclusion, the present results add to the existing knowledge, showing that (i) duration of AP use is a modifying factor; (ii) that there are also AP users who lose weight; (iii) that AP switch to metabolically more neutral compounds may not result in weight loss in all cases; and (iv) that AP naive patients are more vulnerable to weight gain.

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In another review of atypical neuroleptics (including clozapine, risperidone, olanzapine, sulpiride, tiapride, amisulpride, remoxipride, and clothiapine) for COS, clozapine seemed to have the most robust effect on the symptoms of COS, and risperidone and olanzapine also had utility in the treatment of COS.

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Amisulpride tablets (Sulpitac) are prescribed as oral therapy for the treatment of the long-term symptoms of schizophrenia such as hallucinations.

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Large, high-quality studies have compared newer and older drugs and generally found that newer atypical antipsychotics work no better than older typical antipsychotics such as haloperidol, at least for initial treatment of first-episode schizophrenia Similarly, for treatment of children and adolescents with schizophrenia, both atypical and typical antipsychotics appear to be equally effective, but atypical antipsychotics carry a higher risk for metabolic side effects.

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At study end, changes from baseline in Simpson-Angus Scale scores were rather small, except in the haloperidol treatment group.

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