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Esin RA, Essien OE, Andy J "Amlodipine in the treatment of mild-to-moderate essential hypertension.
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Unlike Amlodipine, Cilnidipine decreased urinary protein excretion and in diabetic patients reduced serum triglyceride.
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Conclusions: The study indicates that unlike Amlodipine, Cilnidipine which inhibits L-and N-type calcium channels will be useful for patients with hypertension and cardiovascular disease, diabetes mellitus or renal disease and proves to be a better alternative to existing calcium channel blockers.
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In Japan, few clinical trials have examined combination treatment with a low-dose thiazide diuretic and a RAS inhibitor for the management of hypertension, chiefly because thiazide diuretics are not commonly used.
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Coadministration of multiple 10 mg doses of amlodipine with 80 mg of atorvastatin resulted in no significant change in the steady-state pharmacokinetic parameters of atorvastatin.
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Substitute AZOR for its individually titrated components for patients on amlodipine and olmesartan medoxomil.
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May increase dosage of the fixed combination after 2 weeks if additional BP control is needed (up to maximum of olmesartan medoxomil 40 mg, amlodipine 10 mg, and hydrochlorothiazide 25 mg once daily).
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