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Esin RA, Essien OE, Andy J "Amlodipine in the treatment of mild-to-moderate essential hypertension.

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Unlike Amlodipine, Cilnidipine decreased urinary protein excretion and in diabetic patients reduced serum triglyceride.

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Conclusions: The study indicates that unlike Amlodipine, Cilnidipine which inhibits L-and N-type calcium channels will be useful for patients with hypertension and cardiovascular disease, diabetes mellitus or renal disease and proves to be a better alternative to existing calcium channel blockers.

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In Japan, few clinical trials have examined combination treatment with a low-dose thiazide diuretic and a RAS inhibitor for the management of hypertension, chiefly because thiazide diuretics are not commonly used.

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Coadministration of multiple 10 mg doses of amlodipine with 80 mg of atorvastatin resulted in no significant change in the steady-state pharmacokinetic parameters of atorvastatin.

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Substitute AZOR for its individually titrated components for patients on amlodipine and olmesartan medoxomil.

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In the Reduction in Endpoints in Patients with non-Insulin-dependent Diabetes Mellitus with the Angiotensin II Antagonist Losartan (RENAAL) trial, losartan (plus conventional antihypertensive therapy, including calcium channel blockers) was shown to be superior to placebo (plus conventional antihypertensive therapy, including calcium channel blockers) in type II diabetics with nephropathy in preventing the composite end point of end-stage renal disease, doubling of serum creatinine, or death.

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May increase dosage of the fixed combination after 2 weeks if additional BP control is needed (up to maximum of olmesartan medoxomil 40 mg, amlodipine 10 mg, and hydrochlorothiazide 25 mg once daily).

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