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In UA/NSTEMI and STEMI sufferers present process non-major PCI, the use of fondaparinux as the sole anticoagulant during PCI is not really helpful as a result of an increased threat of guiding catheter thrombus (see medical research section 5.1). Therefore adjunctive UFH must be used during non-primary PCI based on standard apply (see posology in part 4.2). For remedy of superficial-vein thrombosis - Fondaparinux must be used with caution in patients who're being handled concomitantly with different medicinal products that enhance the risk of haemorrhage. For prevention of VTE- Agents that will improve the risk of haemorrhage should not be administered concomitantly with fondaparinux.

Patient Drug Information

When treating a blood clot, one other "blood thinner" is normally started within three days after you begin utilizing fondaparinux. Your doctor will direct you to use each of these medications till the warfarin is working well.

It binds to antithrombin resulting in a conformational change within the antithrombin molecule, thereby tremendously potentiating its inhibition of issue Xa.Factor Xa inhibitors could be administered both orally or parenterally and inhibit Factor Xa indirectly since their effect is mediated via antithrombin.Fondaparinux is a pentasaccharide obtained by chemical synthesis.

Presence of superficial-vein thrombosis larger than three cm from the sapheno-femoral junction should be confirmed and concomitant DVT ought to be excluded by compression ultrasound or objective strategies previous to initiating treatment of fondaparinux. There are not any information relating to the usage of fondaparinux 2.5 mg in superficial-vein thrombosis sufferers with concomitant DVT or with superficial-vein thrombosis within 3 cm of the sapheno-femoral junction (see section 4.2 and 5.1).



If co-administration is essential, shut monitoring is important. • Treatment of superficial-vein thrombosis - The security and efficacy of fondaparinux in patients with physique weight less than 50 kg has not been studied, due to this fact fondaparinux is not beneficial to be used in these patients (see section four.4). • Treatment of superficial-vein thrombosis - The security and efficacy of fondaparinux in patients with extreme hepatic impairment has not been studied, subsequently fondaparinux is not recommended to be used in these sufferers (see section four.four). In STEMI or UA/NSTEMI patients who're to undergo coronary artery bypass graft surgical procedure, fondaparinux the place possible, should not be given through the 24 hours before surgery and could also be restarted 48 hours publish-operatively. The first dose of fondaparinux is administered intravenously and subsequent doses are administered by subcutaneous injection.

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