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Our data show that, as compared with placebo or with other antidiabetic regimens, treatment with rosiglitazone was associated with a significant increase in the risk of myocardial infarction and with an increase in the risk of death from cardiovascular causes that was of borderline significance.
Key secondary end points were changes from baseline in weight and mean daily glucose (MDG) at week 24.
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Decision modeling is useful when clinical questions remain about how to target an empirically established clinical preventive service at the individual or program level or when complex determinations of magnitude of net benefit, overall or among important subpopulations, are required.
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Given the drug use indication, likely due to hyperglycemia over time, which, however, was not available in the data analysis, the analysis of time-dependent pioglitazone usage in Cox models might lead to misleading conclusions regarding its risk associations with cancer.
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In the Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycemia in Diabetes (RECORD) trial, rosiglitazone (plus metformin or a sulfonylurea) was compared with metformin plus a sulfonylurea in the combined endpoint of hospitalization or cardiovascular death.
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Methods: This is a retrospective analysis of a convenience sample of 199 patients who were prescribed pioglitazone therapy over a 6-month period.
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Pioglitazone modulates the proliferation and apoptosis of vascular smooth muscle cells via peroxisome proliferators-activated receptor-gamma.
Monitoring is especially important in older adults because the dose required may decrease with age.
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Thus, both insulin resistance and oxidative stress are attractive targets for therapy in patients with this disease.
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Moreover, this increase in body weight in insulin-treated patients receiving pioglitazone was correlated with the decline in HbA 1c.
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The prespecified secondary endpoints, in order of priority, were: time to the first event of death from any cause, myocardial infarction (excluding silent myocardial infarction), and stroke (main secondary endpoint in rest of this report); cardiovascular death; and time to individual components of the primary composite endpoint.
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It is usually mild and can be treated quickly and easily by eating or drinking a small amount of glucose-rich food.
However, a randomized, double-blind, placebo-controlled, crossover study by Rennings et al found that response to the loop diuretics furosemide and amiloride were preserved in rosiglitazone-treated subjects with insulin resistance.
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