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There are no plans to disseminate the results of the research to study participants or the relevant patient community.
The original sulfonylurea agents are now known as the first-generation sulfonylureas.
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This study, in more than 5000 high-risk patients with type 2 diabetes and a history of macrovascular disease, investigated whether pioglitazone added to standard contemporary multifactorial treatment could improve mortality and morbidity associated with major CVD progression ().
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Drucker DJ, Buse JB, Taylor K, Kendall DM, Trautmann M, Zhuang D, et al.
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We also conducted an analysis of the glycemic control and insulin dose changes in patients categorized as more insulin-resistant (defined as baseline insulin dose and HbA 1c both median or greater) compared with less insulin-resistant patients (defined as baseline insulin dose and HbA 1c both less than median) as a potential index of insulin sensitivity.
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However, if you do not remember until the next day, skip the missed dose and continue your regular dosing schedule.
Metformin is often associated with weight loss making it a preferred, first line agent for management of overweight patients with type 2 diabetes.
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There have been postmarketing reports of hepatic failure, including fatalities, in patients taking pioglitazone.
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