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Acebutolol has been shown to delay AV conduction time and to increase the refractoriness of the AV node without significantly affecting sinus node recovery time, atrial refractory period, or the HV conduction time.

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In addition, a meta-analysis addressed whether a goal of less than 70 mg per dL or less than 100 mg per dL was better, and found that more intensive treatment resulted in an NNT of 20 over one to five years to prevent one MI or cardiovascular death.

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Recommend weekly checking of pulse for 1 full minute or daily recording of pulse before medication and during exercise as appropriate.

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In addition to diuretic therapy, vasodilators are recommended as first-line therapy for patients with acute heart failure in the absence of hypotension, for relief of symptoms.

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