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When fully developed with the three clinical elements of uric acid overproduction, neurologic dysfunction, and cognitive and behavioral disturbances, the diagnosis of Lesch-Nyhan syndrome is made readily.
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Concurrent drug therapy issues: ACE inhibitors: The risk of hypersensitivity may be increased in patients receiving ACE inhibitors.
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This analogy is important both for conceptualizing the uric acid crystals in the joint and for understanding the various types of gout treatment (see below), some of which attack the inflammation (pour water on the flaming matches) and some of which remove the uric acid crystals (take away the matches).
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The two replicate Phase III studies, CLEAR1 and CLEAR2, evaluated lesinurad (200mg or 400mg oral) in combination with allopurinol in symptomatic gout patients not achieving target sUA levels on their current allopurinol dose.
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